A Proposed Total Synthesis of Sesquiterpenoids from Chrysanthemum indicum

Weng Xiujie, Tsz Kiang, Wufei Ji

2022

Abstract

The proposed retrosynthesis of a guaianolide-type sesquiterpenoid. The first route begins with the construction of a 5,7,5-ring sesquiterpenoid through the connection a, ß-cyclopentenone derivative from Pauson-Khand reaction and trans lactone by a special Barbier reagent. Firstly, angelic acid is used to complete the synthesis via esterification with enclosing central ring sesquiterpenoid. The second route starts with the fabrication of a modified trans configured lactone with methylene. A following Pauson-Khand reaction appends a, ß-cyclopentenone on the lactone. Finally, angelic acid completes the synthesis by esterification with exterior hydroxy of sesquiterpenoid.

Paper Citation

in Harvard Style

Xiujie W., Kiang T. and Ji W. (2022). A Proposed Total Synthesis of Sesquiterpenoids from Chrysanthemum indicum. In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB, ISBN 978-989-758-595-1, pages 666-670. DOI: 10.5220/0011253200003443

in Bibtex Style

@conference{icbeb22,
author={Weng Xiujie and Tsz Kiang and Wufei Ji},
title={A Proposed Total Synthesis of Sesquiterpenoids from Chrysanthemum indicum},
booktitle={Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,},
year={2022},
pages={666-670},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0011253200003443},
isbn={978-989-758-595-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics - Volume 1: ICBEB,
TI - A Proposed Total Synthesis of Sesquiterpenoids from Chrysanthemum indicum
SN - 978-989-758-595-1
AU - Xiujie W.
AU - Kiang T.
AU - Ji W.
PY - 2022
SP - 666
EP - 670
DO - 10.5220/0011253200003443