Therapeutic Effect of Trimetazidine Combined with Traditional

Chinese Medicine Prescription on Senile Heart Failure Complicated

with Pulmonary Infection

Hua Li, Zhixia Sun, Binbin Zang and Shixiang Hu

Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan,

450000, China

Keywords:

Trimetazidine, Traditional Chinese Medicine, Elderly, Heart Failure with Pulmonary Infection, Clinical

Efficacy.

Abstract:

Objective: To explore the clinical effect of the combined use of trimetazidine and traditional Chinese medicine

in the treatment of elderly patients with heart failure and pulmonary infection. Choose to start a comparative

experiment in our hospital. The researcher's object is elderly patients with heart failure and lung infection.

The study period is from April 2020 to April 2021. A total of 80 patients were selected in this study, and

different methods were applied when the patients were treated. The research methods were simple Chinese

medicine treatment (control group) and trimetazidine combined with Chinese medicine treatment

(experimental group) to compare and analyze the clinical treatment effects of the two groups of patients.

Results: In terms of treatment effect, the two groups reached 95.00% and 80.00% respectively. In contrast,

the experimental group has higher data, and the discharge time of the experimental group and the

disappearance of various symptoms are shorter than the control group. The patient's physical sign scores were

closer to the normal value, and the differences from the control group were relatively large, expressed as

P<0.05, which was statistically significant. In the process of treatment of elderly patients with heart failure

and pulmonary infection, the combined use of trimetazidine and traditional Chinese medicine can promote

the recovery of patients and improve the clinical symptoms of patients. The clinical application effect is

significant.

1 INTRODUCITON

As far as elderly patients are concerned, most of them

have already experienced physical decline. Not only

does the patient's physical ability decrease, but it is

also easy to cause the patient to have a weakened

myocardial contraction or myocardial diastolic

capacity, resulting in a low stroke volume of the

patient, and it is difficult to meet the patient's body

needs, showing heart failure (

Chen 2020). For most

patients with heart failure, it mostly starts with the

failure of the left heart. The patient's initial clinical

symptoms are pulmonary congestion, and as it

progresses gradually, the patient is prone to

secondary bronchitis and pneumonia symptoms.

Therefore, it is particularly important to carry out

effective treatment for patients and reduce the

incidence of adverse reactions in patients. According

to the results of relevant research data, the combined

use of trimetazidine and traditional Chinese medicine

can relieve the symptoms of patients and has

significant clinical application significance (

Ji 2019).

This study is based on this, taking patients in our

hospital as an example, applying different treatment

methods, and conducting comparative studies on the

results as follows.

2 PURPOSE

When the condition of patients with heart failure and

lung infection is more serious, it is a serious threat to

the life and health of the patients. Therefore, it is

particularly important to carry out active treatment

for the patients. In this study, different treatment

methods were applied, and the clinical application

value of trimetazidine and traditional Chinese

medicine prescriptions was explored by comparing

the clinical effects.

Li, H., Sun, Z., Zang, B. and Hu, S.

Therapeutic Effect of Trimetazidine Combined with Traditional Chinese Medicine Prescription on Senile Heart Failure Complicated with Pulmonary Infection.

DOI: 10.5220/0011312800003443

In Proceedings of the 4th International Conference on Biomedical Engineering and Bioinformatics (ICBEB 2022), pages 897-900

ISBN: 978-989-758-595-1

897

3 METHOD

3.1 General Data Analysis

From April 2020 to April 2021, research work has

been carried out in our hospital, taking patients with

heart failure and lung infection as an example. The 80

patients under the regulations were divided into

groups, and different treatment methods were

applied. They were given simple medication and

combined medication, respectively, and the group

names were control and experiment. In a specific

comparative experiment, in the 40 patients in the

experimental group, the number of males was 23 and

the number of females was 17. The maximum age of

the patients was 88 years old, the minimum age was

61 years old, and the mean was (73.22±4.33) years

old. Among the 40 patients in the control group, there

were 24 males and 16 females. The age range of the

patients was 63-89 years, with an average of

(74.00±4.83) years. The general data of the two

groups of patients were compared under statistical

methods, and the differences in the data were not

significant enough, P>0.05. Shows that the treatment

effect can be compared as a variable.

Inclusion criteria: The patients were in

compliance with the clinical diagnostic criteria for

heart failure complicated with pulmonary infection;

the patients had no history of drug allergy; this study

was approved by the hospital ethics committee and

was carried out after the patient's consent.

Exclusion criteria: patients with malignant

tumors; patients with liver, kidney and other organ

dysfunction diseases, patients with consciousness

disorders.

3.2 Research Methods

Patients in the control group were treated with

traditional Chinese medicine prescriptions. The main

prescriptions included: Ephedra sinica 10g,

Motherwort 30g, Ophiopogon japonicus 30g,

Adenophora 30g, Radix scoparia 15g, Almond 15g,

Gypsum 30g, Peach kernel 15g, Platycodon 10g,

Shegan 10g, Ophiopogon 30g, Danshen 15g,

Mulberry Bark 15g, Roasted Licorice 10g, 1 dose per

day, once a day. If the patient has obvious symptoms

of qi deficiency, atractylodes macrocephala and

astragalus should be added. If the patient has obvious

yang deficiency, Guizhi needs to be added. If the

patient has obvious yin deficiency, it is necessary to

increase Polygonatum and Cornus. If the patient has

obvious congestion, leeches and safflower need to be

added. If the patient has obvious edema, add

Eupatorium and Poria.

In the experimental group, on the basis of

traditional Chinese medicine decoction treatment,

trimetazidine was added with a dose of 20 mg, and

intervention was performed three times a day. Both

groups of patients received 1 month of treatment.

3.3 Observation Indicators

The comparison of treatment effects mainly includes

three indicators: markedly effective, effective and

ineffective. Significant effect mainly refers to the

disappearance of the symptoms of lung infection after

the patient receives treatment; under the X-ray film,

the patient shows that the inflammatory reaction

focus disappears. Effective means that the patient’s

symptoms of pulmonary infection have improved

after receiving treatment; with the help of X-ray

observation, the elimination rate of inflammatory

lesions of the patient is above 60%. Ineffective means

that the patient's clinical symptoms and indicators

have not changed significantly after treatment. The

exclusion invalid rate is the total effective rate.

The hospitalization time and the disappearance

time of related symptoms of the two groups of

patients were compared. The symptoms mainly

included cough, wheezing, and wet rales.

The physical signs of the two groups of patients

were compared, including heart rate (HR), respiratory

rate (RR), arterial partial pressure of oxygen (PaO2),

and arterial partial pressure of carbon dioxide

(PaCO2).

3.4 Statistical Methods

The statistical software SPSS20.0 was used as a tool

to perform statistical analysis on the data appearing

in this study. The comparison result of measurement

data (x±s) shall be verified by t value. The

comparison result of the count data (n, %) is verified

by the x2 value. When the result shows P<0.05, it

means that there is a statistical analysis value for the

difference between the groups.

4 RESULTS

4.1 Therapeutic Effect

In terms of treatment effect, the two groups reached

95.00% and 80.00% respectively. In contrast, the

experimental group was higher, and the data

difference was statistically significant (P<0.05).

ICBEB 2022 - The International Conference on Biomedical Engineering and Bioinformatics

898

Table 1: Comparison of the treatment effect of the two groups of patients [n(%)].

Groups

Markedly

effective

Effective Ineffective Efficient

Experience

Group (n=40)

26 (65.00) 12 (30.00) 2 (5.00) 38 (95.00)

Control Group

(n=40)

17 (42.50) 15 (37.50) 8 (20.00) 32 (80.00)

6.866

P <0.05

4.2 Time to Disappearance of Symptoms

Compared with patients in the control group, patients

in the experimental group had shorter hospital stays,

and the disappearance of symptoms such as cough,

wheezing and wet rales was shorter, with large data

differences (P<0.05).

Table 2: Comparison of disappearance of symptoms between the two groups (x±s).

Grou

s Hos

ital sta

(

)

Cou

(

)

Asthma

(

)

Wet rales

(

)

Experience

Group (n=40)

7.33±1.23

5.33±1.00

2.13±1.22 4.30±1.21

Control Group

(n=40)

9.89±2.31 7.56±1.20 3.49±1.22 6.58±1.20

t 5.483 6.004 5.284 6.284

P <0.05 <0.05 <0.05 <0.05

4.3 Sign Comparison

After treatment, compared with the control group, the

HR, RR and PaCO2 of the experimental group were

lower than those of the control group. However,

PaO2 was significantly higher than the control group,

and the differences in various data were expressed as

P<0.05, which was meaningful.

Table 3: Comparison of vital signs of the two groups of patients (x±s).

Grou

s HR RR PaO

PaCO

Experience

Group (n=40)

82.33±10.24 26.04±4.23 67.45±14.22 51.29±9.83

Control Group

(n=40)

86.55±12.03 28.99±5.48 53.49±13.23 57.98±10.92

t 7.494 5.482 6.224 7.285

P <0.05 <0.05 <0.05 <0.05

5 CONCLUSION

The main factor leading to heart failure is the heavier

ventricular load of patients in systole or diastole,

which leads to changes in the number and quality of

the patient's cardiomyocytes, and decreases in

ventricular diastolic and systolic function in patients

(Wang, Xie, Li, et al. 2019) According to the results

of relevant research data, when a patient has heart

failure, it will cause the patient to have pulmonary

congestion. As a result, pulmonary infection is

formed, and pulmonary infection will lead to an

increase in the patient's body metabolism. To

maximize myocardial oxygen consumption and

increase the patient's heart load, the two interacts

form a vicious circle (Wang 2020). In actual

development, bronchial mucosal secretion caused by

infection will show a general trend of increase.

Bronchial spasm and inflammation of the bronchial

wall will change, which has a serious impact on the

Therapeutic Effect of Trimetazidine Combined with Traditional Chinese Medicine Prescription on Senile Heart Failure Complicated with

Pulmonary Infection

899

exchange of gas in the patient's lungs. Increase the

patient's lung pressure, and then increase the patient's

right heart conformity, the patient has respiratory

failure and heart failure. In the case of respiratory

failure, it will cause the decrease of CaO2 and PH and

promote the increase of CaCO2. Patients are prone to

damage to the intima of alveolar capillaries,

secondary to hypoxemia, pulmonary edema, and

acidosis, which pose a greater threat to the patient’s

health (Liu 2019).

Trimetazidine is a new drug, mainly used in anti-

myocardial ischemia, which can reduce the number

of angina pectoris in patients. The corresponding cell

protection is mainly through the inhibition of

mitochondrial long-chain 3-KAT. Promote

myocardial energy metabolism into glucose

oxidation, promote energy output, and reduce oxygen

free radicals. Promote the full play of anti-myocardial

ischemia and cell protection, and improve the heart

function of patients (Nie 2020). The decoction of

traditional Chinese medicine can achieve the effects

of eliminating phlegm, relieving spasm, relieving

cough and relieving asthma. Among them, Shegan

has the effect of clearing away heat and

detoxification. When used together with ephedra, it

has the effect of promoting lungs and relieving

asthma. It can relieve sweating and relieve cough and

diuresis (Zheng 2019). The clinical application effect

is remarkable. When the two drugs are used in

combination, it is more conducive to promoting the

recovery of patients with heart failure and pulmonary

infection (Zheng, Yang, Cao, et al. 2019).

To sum up, in the treatment of elderly patients

with heart failure and pulmonary infection,

trimetazidine and traditional Chinese medicine

decoction are used in combination. It is more

conducive to promoting the improvement of clinical

treatment effects and improving the symptoms of

patients. It is significant to promote the recovery of

patients and can be promoted and used.

In the process of writing this thesis, I strengthened

my professional understanding. I learned more about

the principles of being a person and doing things, so

that I have a deeper understanding of issues in related

professional fields. As this article is about to close, I

would like to sincerely thank the people who have

helped me. Thank you for the thought guidance for

me in the process of writing this thesis. Thank you for

your careful guidance during the creation of the

thesis. Thank you for reviewing me carefully when

the paper is finished. Wish: The students are

successful in their studies, and the teachers have

pupils everywhere.

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